#14 - 🔬 Breakthrough: Islet Cells Without Immunosuppression

Hey readers! 🌟 Exciting developments in the T1D world this week as we explore a groundbreaking islet cell transplant that doesn't require immunosuppression. From revolutionary research to practical back-to-school advice, we've gathered the most impactful stories to keep you informed and inspired on your diabetes journey.

New data: Hypoimmune islets survive with no immunosuppression — Sana Biotechnology's first-in-human study shows genetically engineered islets producing insulin without immunosuppressants, potentially revolutionizing T1D treatment. — Sandy Vogt, Ph.D.

Novel T1D Therapy Opens the Door to Cell Transplants Sans Immunosuppressants — A man with long-standing T1D received gene-edited islet cells without immunosuppression, showing no immune rejection after 12 weeks and a 42% reduction in HbA1c. — @medpagetoday

Mayo Clinic researchers find "sugar coating" cells can protect those typically destroyed in type 1 diabetes — Researchers discovered that adding sialic acid to beta cells (the same trick cancer cells use to evade detection) protected them from immune attack with 90% effectiveness in preclinical models.

Brain might become target of type 1 diabetes treatments — UW Medicine research shows leptin can resolve diabetic ketoacidosis without insulin, challenging conventional understanding and potentially reducing the burden of daily insulin management.

The Transformative Impact of Automated Insulin Delivery Systems — A mother shares how automated insulin delivery systems dramatically improved her daughter's health after 28 years with T1D, calling the technology "transformational."

Tandem, Insulet monitoring CMS payment proposal for diabetes tech — CMS proposes shifting insulin pumps and CGMs to a monthly rental model instead of upfront purchases, though major manufacturers don't expect significant business impacts.

Device Finder - DIY Loop vs twiist — A comparison between DIY Loop and the newly FDA-approved twiist AID system, which can be controlled directly from an Apple Watch.

Snaq. A diabetes AI to help you carb count. Badly. — This AI app for carb counting receives harsh criticism for poor food recognition and accuracy, with the reviewer giving it just 1/5 stars.

Going back to school with type 1 diabetes — Essential guidance for parents and students navigating the school environment with T1D, including the importance of 504 Plans and communication with school staff.

Skip the Struggle: A Guide for Newly Diagnosed Type 1 Diabetes Management — Scott Benner emphasizes understanding the principles behind diabetes management rather than just following rigid rules, noting "It's not stacking if you need it — that's bolusing."

#1597 Advice for T1 Parents from T1 Adults - Part 2 — Adults with T1D share valuable insights for parents, emphasizing the importance of involving children in their own care early and fostering independence.

This Isn't About Barbie. It's About Us. — DiabetesDad reflects on the 'Barbie with Diabetes' doll, highlighting the greater need for mentorship and community support for children with T1D.

Udaipur Type 1 Diabetes Summit Drives Access, Equity, and Action — A collaborative summit in India brought together stakeholders to create a roadmap for improving T1D management and reducing stigma across the country.

#1594 Molly's Game — A mother shares her daughter's complicated T1D diagnosis, which included rare acute esophageal necrosis due to diabetic ketoacidosis, emphasizing the importance of timely medical care.

Debunking Misconceptions and Understanding the Stages of Type 1 Diabetes — Clinical pharmacist Jennifer Goldman explains the three stages of T1D and how teplizumab can delay progression from stage 2 to stage 3 by 2-3 years, highlighting the importance of early screening.

That's all for this week! What research breakthrough are you most excited about? Hit reply to share your thoughts or ask questions.

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