Hey readers! 🌟 Exciting developments in the T1D world this week as we explore a groundbreaking islet cell transplant that doesn't require immunosuppression. From revolutionary research to practical back-to-school advice, we've gathered the most impactful stories to keep you informed and inspired on your diabetes journey.
This Week's Research Breakthroughs 🧪
New data: Hypoimmune islets survive with no immunosuppression — Sana Biotechnology's first-in-human study shows genetically engineered islets producing insulin without immunosuppressants, potentially revolutionizing T1D treatment. — Sandy Vogt, Ph.D.
Novel T1D Therapy Opens the Door to Cell Transplants Sans Immunosuppressants — A man with long-standing T1D received gene-edited islet cells without immunosuppression, showing no immune rejection after 12 weeks and a 42% reduction in HbA1c. — @medpagetoday
Mayo Clinic researchers find "sugar coating" cells can protect those typically destroyed in type 1 diabetes — Researchers discovered that adding sialic acid to beta cells (the same trick cancer cells use to evade detection) protected them from immune attack with 90% effectiveness in preclinical models.
Brain might become target of type 1 diabetes treatments — UW Medicine research shows leptin can resolve diabetic ketoacidosis without insulin, challenging conventional understanding and potentially reducing the burden of daily insulin management.
Technology & Treatment Updates 📱
The Transformative Impact of Automated Insulin Delivery Systems — A mother shares how automated insulin delivery systems dramatically improved her daughter's health after 28 years with T1D, calling the technology "transformational."
Tandem, Insulet monitoring CMS payment proposal for diabetes tech — CMS proposes shifting insulin pumps and CGMs to a monthly rental model instead of upfront purchases, though major manufacturers don't expect significant business impacts.
Device Finder - DIY Loop vs twiist — A comparison between DIY Loop and the newly FDA-approved twiist AID system, which can be controlled directly from an Apple Watch.
Snaq. A diabetes AI to help you carb count. Badly. — This AI app for carb counting receives harsh criticism for poor food recognition and accuracy, with the reviewer giving it just 1/5 stars.
Back to School with T1D 🎒
Going back to school with type 1 diabetes — Essential guidance for parents and students navigating the school environment with T1D, including the importance of 504 Plans and communication with school staff.
Skip the Struggle: A Guide for Newly Diagnosed Type 1 Diabetes Management — Scott Benner emphasizes understanding the principles behind diabetes management rather than just following rigid rules, noting "It's not stacking if you need it — that's bolusing."
Community Voices 🗣️
#1597 Advice for T1 Parents from T1 Adults - Part 2 — Adults with T1D share valuable insights for parents, emphasizing the importance of involving children in their own care early and fostering independence.
This Isn't About Barbie. It's About Us. — DiabetesDad reflects on the 'Barbie with Diabetes' doll, highlighting the greater need for mentorship and community support for children with T1D.
Udaipur Type 1 Diabetes Summit Drives Access, Equity, and Action — A collaborative summit in India brought together stakeholders to create a roadmap for improving T1D management and reducing stigma across the country.
#1594 Molly's Game — A mother shares her daughter's complicated T1D diagnosis, which included rare acute esophageal necrosis due to diabetic ketoacidosis, emphasizing the importance of timely medical care.
Understanding T1D Stages 📊
Debunking Misconceptions and Understanding the Stages of Type 1 Diabetes — Clinical pharmacist Jennifer Goldman explains the three stages of T1D and how teplizumab can delay progression from stage 2 to stage 3 by 2-3 years, highlighting the importance of early screening.
That's all for this week! What research breakthrough are you most excited about? Hit reply to share your thoughts or ask questions.
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